It requires a 120-gallon or larger aquarium. It is a very peaceful species except when housed with other rabbitfish. The Blue Spotted Rabbitfish may be housed with more aggressive fish and can be kept in pairs. Its predators will tend to leave it alone because of its venomous dorsal spines which it can raise when disturbed. Care must be taken when handling this fish to avoid the possibility of being stung by its venomous spines. Rabbitfish are generally reef-safe if they are well fed. If not, it is possible for them to nip at and consume some species of LPS and soft corals.
Its diet consists of a variety of fresh vegetables and algae. It does nip and possibly eat some soft and hard coral polyps